Absolute cutting edge research in the latest (July 2006) edition of Radiology journal--M. Beth McCarville et al write about "Angiogenesis Inhibitors in a Murine Neuroblastoma Model: Quantitative Assessment of Intratumoral Blood Flow with Contrast-enhanced Gray-Scale US "
Their results support the hypothesis that gray-scale US measurements of microbubble contrast agent flow can be used to measure the functional consequences of antiangiogenic therapy in orthotopic tumors, and, at least to some degree, they reflect histologic changes in tumor vascularity. Radiology 2006 240: 73-81 (DOI: 10.1148/radiol.2401050709). Contrary to the previous use of US contrast with doppler/ power doppler images the authors have used grey scale US to assess tumors. Read about this at http://radiology.rsnajnls.org/cgi/content/abstract/240/1/73
The full text article is available at IRIA HQ and can be viewed only at IRIA house.
There is also an editorial about this research in the same issue: "Will Improved Assessment of Response to Antiangiogenic Therapies Be Achieved with Contrast-enhanced Gray-Scale US?" authored by Jonathan B. Kruskal
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